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Article

More than half of yeast U1 snRNA is dispensable for growth.

Nucleic acids research - 11 Dec 1991

Siliciano P G, Kivens W J, Guthrie C

Abstract excerpt

Yeast U1 snRNA (568 nucleotides) is 3.5-fold larger than its mammalian counterpart (164 nucleotides) and contains apparent sequence homology only at the 5' and 3' ends. We have used deletion analysis to determine whether the yeast-specific U1 sequences play essential roles in vivo. Yeast cells carrying a deletion of more than 60% (355 nucleotides) of the single-copy U1 gene are viable, though slow-growing, while...

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Identifiers

PMID: 1754372
DOI: 10.1093/nar/19.23.6367
PMCID: PMC329179

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More than half of yeast U1 snRNA is dispensable for growth.PMID 1754372Read ↗

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