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Article

Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.

Genes & development - 1 Dec 1990

Ares M, Igel A H

Abstract excerpt

U2 snRNA is an essential component of the splicing apparatus in eukaryotic cells. Three possible secondary structures for the highly conserved 5' half of U2 snRNA are consistent with U2 phylogenetic sequence variation. To distinguish among these models and to test the function of U2 structural elements, we made greater than 35 mutations in the yeast U2 snRNA gene. Some of the mutations were designed in pairs so...

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Identifiers

PMID: 2269428
DOI: 10.1101/gad.4.12a.2132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.PMID 2269428Read ↗

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