Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.

doi:10.1101/gad.4.12a.2132

Back to search

Article

Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.

Genes & development - 1 Dec 1990

Ares M, Igel A H

Abstract excerpt

U2 snRNA is an essential component of the splicing apparatus in eukaryotic cells. Three possible secondary structures for the highly conserved 5' half of U2 snRNA are consistent with U2 phylogenetic sequence variation. To distinguish among these models and to test the function of U2 structural el...

Topics

Base Sequence
Genes, Suppressor
Genetic Complementation Test
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Phenotype
Phylogeny
Potassium Chloride
RNA Splicing
RNA, Small Nuclear
Temperature
Yeasts

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.