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Article

The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.

RNA (New York, N.Y.) - 1 Aug 2002

Ryan Daniel E, Abelson John

Abstract excerpt

In the pre-mRNA processing machinery of eukaryotic cells, U6 snRNA is located at or near the active site for pre-mRNA splicing catalysis, and U6 is involved in catalyzing the first chemical step of splicing. We have further defined the roles of key features of yeast U6 snRNA in the splicing process. By assaying spliceosome assembly and splicing in yeast extracts, we found that mutations of yeast U6 nt 56 and 57...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12212854
DOI: 10.1017/s1355838202025013
PMCID: PMC1370321

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.PMID 12212854Read ↗

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Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors.Semantic proximity Read ↗

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