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Article

Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia.

The Journal of biological chemistry - 17 Jun 2011

Isomura Ryo, Kitajima Ken, Sato Chihiro

Abstract excerpt

Polysialic acid (polySia), a unique acidic glycan modifying neural cell adhesion molecule (NCAM), is known to regulate embryonic neural development and adult brain functions. Polysialyltransferase STX is responsible for the synthesis of polySia, and two single nucleotide polymorphisms (SNPs) of the coding region of STX are reported from schizophrenic patients: SNP7 and SNP9, respectively, giving STX(G421A) with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21464126
DOI: 10.1074/jbc.M111.221143
PMCID: PMC3122212

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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