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Article

Chlorpromazine Increases the Expression of Polysialic Acid (PolySia) in Human Neuroblastoma Cells and Mouse Prefrontal Cortex.

International journal of molecular sciences - 24 May 2017

Abe Chikara, Nishimura Saki, Mori Airi, Niimi Yuki, Yang Yi, Hane Masaya, Kitajima Ken, Sato Chihiro

Abstract excerpt

The neural cell adhesion molecule (NCAM) is modified by polysialic acid (polySia or PSA) in embryonic brains. In adult brains, polySia modification of NCAM is only observed in restricted areas where neural plasticity, remodeling of neural connections, or neural generation is ongoing although the amount of NCAM remains unchanged. Impairments of the polySia-expression and several single nucleotide polymorphisms...

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Source

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Identifiers

PMID: 28538701
DOI: 10.3390/ijms18061123
PMCID: PMC5485947

Genes

CPZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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