Article
The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation.
The Journal of biological chemistry - 8 Mar 2013
Thompson Matthew G, Foley Deirdre A, Colley Karen J
Abstract excerpt
The neural cell adhesion molecule (NCAM) is the major substrate for the polysialyltransferases (polySTs), ST8SiaII/STX and ST8SiaIV/PST. The polysialylation of NCAM N-glycans decreases cell adhesion and alters signaling. Previous work demonstrated that the first fibronectin type III repeat (FN1) of NCAM is required for polyST recognition and the polysialylation of the N-glycans on the adjacent Ig5 domain. In this...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- COS Cells
- Chlorocebus aethiops
- Fibronectins
- Glycosylation
- Immunoblotting
- Immunoglobulins
- Microscopy, Fluorescence
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Neural Cell Adhesion Molecules