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Article

Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule.

The Journal of biological chemistry - 30 Dec 2005

Weinhold Birgit, Seidenfaden Ralph, Röckle Iris, Mühlenhoff Martina, Schertzinger Frank, Conzelmann Sidonie, Marth Jamey D, Gerardy-Schahn Rita, Hildebrandt Herbert

Abstract excerpt

Poly-alpha2,8-sialic acid (polySia) is a unique modification of the neural cell adhesion molecule, NCAM, tightly associated with neural development and plasticity. However, the vital role attributed to this carbohydrate polymer has been challenged by the mild phenotype of mice lacking polySia due to NCAM-deficiency. To dissect polySia and NCAM functions, we generated polySia-negative but NCAM-positive mice by...

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PMID: 16267048
DOI: 10.1074/jbc.M511097200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule.PMID 16267048Read ↗

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