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Article

Identification of a buried β-strand as a novel disease-related motif in the human polysialyltransferases.

The Journal of biological chemistry - 1 Jan 2024

Hatanaka Rina, Hane Masaya, Hayakawa Kaito, Morishita Sayo, Ohno Shiho, Yamaguchi Yoshiki, Wu Di, Kitajima Ken, Sato Chihiro

Abstract excerpt

The polysialyltransferases ST8SIA2 and ST8SIA4 and their product, polysialic acid (polySia), are known to be related to cancers and mental disorders. ST8SIA2 and ST8SIA4 have conserved amino acid (AA) sequence motifs essential for the synthesis of the polySia structures on the neural cell adhesion molecule. To search for a new motif in the polysialyltransferases, we adopted the in silico Individual Meta Random...

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Identifiers

PMID: 38103644
DOI: 10.1016/j.jbc.2023.105564
PMCID: PMC10828065

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