Article

ST8SIA4-mediated polysialylation is critical for CCR2-driven monocyte egress from the bone marrow

2026-01-28

Abstract excerpt

<title>Abstract</title> <p>Polysialylation is a rare post-translational modification critical for brain development and synaptic plasticity. Although also present on circulating leukocytes, its immune functions remain poorly understood. Analysis of human genomic data revealed that natural variants of ST8SIA4, which encodes a key polysialylation enzyme, are associated with reduced circulating monocyte counts. Usin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f743baa6-0b0d-576b-83e9-f99c77e3239e
DOI: 10.21203/rs.3.rs-8650461/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ST8SIA4-mediated polysialylation is critical for CCR2-driven monocyte egress from the bone marrowDOI 10.21203/rs.3.rs-8650461/v1Read

ST8SIA4-mediated polysialylation is critical for CCR2-driven monocyte egress from the bone marrowSemantic proximity Read

Impact of structural aberrancy of polysialic acid and its synthetic enzyme ST8SIA2 in schizophreniaSemantic proximity Read

Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.Semantic proximity Read

Molecular characterization of eukaryotic polysialyltransferase-1.Semantic proximity Read

Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders.Semantic proximity Read

Characterisation of genetic variation in ST8SIA2 and its interaction region in NCAM1 in patients with bipolar disorder.Semantic proximity Read

Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.Semantic proximity Read

Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior.Semantic proximity Read

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 geneSemantic proximity Read

Polysialylation is a general feature of immune activationSemantic proximity Read

Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditionsSemantic proximity Read

ST8Sia2 polysialyltransferase protects against infection by <i>Trypanosoma cruzi</i>Semantic proximity Read