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Article

The impact of N-glycosylation on the functions of polysialyltransferases.

The Journal of biological chemistry - 7 Sept 2001

Mühlenhoff M, Manegold A, Windfuhr M, Gotza B, Gerardy-Schahn R

Abstract excerpt

Poly-alpha-2,8-sialic acid (polysialic acid) is a post-translational modification of the neural cell adhesion molecule (NCAM) and an important regulator of neuronal cell-cell interactions. The synthesis of polysialic acid depends on the two polysialyltransferases ST8SiaII and ST8SiaIV. Understanding the catalytic mechanisms of the polysialyltransferases is critical toward the aim of influencing physiological and...

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Identifiers

PMID: 11418591
DOI: 10.1074/jbc.M101022200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The impact of N-glycosylation on the functions of polysialyltransferases.PMID 11418591Read ↗

Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule.Semantic proximity Read ↗

Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV.Semantic proximity Read ↗

Molecular defects that cause loss of polysialic acid in the complementation group 2A10.Semantic proximity Read ↗

The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation.Semantic proximity Read ↗

ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes.Semantic proximity Read ↗

Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule.Semantic proximity Read ↗

Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST.Semantic proximity Read ↗

Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior.Semantic proximity Read ↗

Molecular characterization of eukaryotic polysialyltransferase-1.Semantic proximity Read ↗

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation.Semantic proximity Read ↗

ST8Sia2 polysialyltransferase protects against infection by <i>Trypanosoma cruzi</i>Semantic proximity Read ↗

Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.Semantic proximity Read ↗

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