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Article

Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation.

FEBS letters - 20 Apr 2011

Lahti Jennifer L, Lui Bertrand H, Beck Stayce E, Lee Stephen S, Ly Daphne P, Longaker Michael T, Yang George P, Cochran Jennifer R

Abstract excerpt

Receptor tyrosine kinases (RTKs) regulate critical cell signaling pathways, yet the properties of their cognate ligands that influence receptor activation are not fully understood. There is great interest in parsing these complex ligand-receptor relationships using engineered proteins with altered binding properties. Here we focus on the interaction between two engineered epidermal growth factor (EGF) mutants and...

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Identifiers

PMID: 21439278
DOI: 10.1016/j.febslet.2011.03.044
PMCID: PMC3118396

Genes

EGF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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