Article

Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand binding

2023-02-13

Abstract excerpt

<h4>ABSTRACT</h4> The 58 receptor tyrosine kinases (RTKs) are critically important for human development, and are implicated in many growth disorders and cancers. Here we introduce a methodology to identify and quantify bias in RTK signal transduction across the plasma membrane, and to quantify phosphorylation efficiencies, without contributions from feedback loops and system bias. We show that RTK biased signali...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ecd58161-d942-55d3-99af-751afd3b2a9d
DOI: 10.1101/2023.02.13.528340

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand bindingDOI 10.1101/2023.02.13.528340Read

Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand binding.Semantic proximity Read

An integrated mechanistic and data-driven computational model predicts cell responses to high- and low-affinity EGFR ligandsSemantic proximity Read

The Measurement of Receptor Signaling Bias.Semantic proximity Read

A threshold model for receptor tyrosine kinase signaling specificity and cell fate determinationSemantic proximity Read

EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensorsSemantic proximity Read

Quantification of the effects of mutations on receptor tyrosine kinase (RTK) activation in mammalian cells.Semantic proximity Read

Glioblastoma mutations impair ligand discrimination by EGFRSemantic proximity Read

Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling networkSemantic proximity Read

Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis.Semantic proximity Read

Magnitude of Ubiquitination Determines the Fate of Epidermal Growth Factor Receptor Upon Ligand Stimulation.Semantic proximity Read

Measurement of Receptor Signaling Bias.Semantic proximity Read

BRAF <sup>V600E</sup> -Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor SignalingSemantic proximity Read