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Article

Mechanistic insights into the activation of oncogenic forms of EGF receptor.

Nature structural & molecular biology - 20 Nov 2011

Wang Zhihong, Longo Patti A, Tarrant Mary Katherine, Kim Kwangsoo, Head Sarah, Leahy Daniel J, Cole Philip A

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly activated by mutation in non-small cell lung cancer. The mechanism of this oncogenic activation is not completely understood, but in contrast to that of the wild-type EGFR, it is proposed to be independent of kinase domain dimerization. Mechanistic studies on EGFR have mainly relied on cell-based assays or isolated kinase...

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Identifiers

PMID: 22101934
DOI: 10.1038/nsmb.2168
PMCID: PMC3230693

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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