Article

Effects of N361 Glycosylation on Epidermal Growth Factor Receptor Biological Function

2024-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase that is frequently modified by glycosylation post-translationally. In cancer, EGFR amplifications and hotspot mutations such as L858R that promote proliferation have been detected in a significant fraction of non-small cell lung carcinomas and breast adenocarcinomas. Molecular dynamic simulations suggested that glycosylat...

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Literature Corpus work: 80276b61-ece0-5e73-91d9-49d078beebf2
DOI: 10.1101/2024.07.12.603279

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