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Article

The EGF receptor Hokey-Cokey.

Cancer cell - 1 Mar 2007

Niculescu-Duvaz Dan, Whittaker Steven, Springer Caroline, Marais Richard

Abstract excerpt

In cancer, the epidermal growth factor (EGF) receptor (EGFR) can be activated by mutations that disrupt the inactive conformation and allow the active conformation to predominate. Structural studies have elucidated the molecular events that lead to EGFR activation and shown that small-molecule anti-EGFR drugs can bind to either the inactive or the active conformation of the kinase domain. In this issue of Cancer...

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Source

Identifiers

PMID: 17349577
DOI: 10.1016/j.ccr.2007.02.021

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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