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Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network

11 May 2023

Abstract excerpt

The epidermal growth factor receptor (EGFR) has been studied extensively because of its critical role in cellular signaling and association with disease. Previous models have elucidated interactions between EGFR and downstream adaptor proteins or showed phenotypes affected by EGFR. However, the link between specific EGFR phosphorylation sites and phenotypic outcomes is still poorly understood. Here, we employed a...

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PMID: 37169593
DOI: 10.26508/lsa.202201466

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