Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand binding.

Abstract excerpt

Signaling bias is the ability of a receptor to differentially activate downstream signaling pathways in response to different ligands. Bias investigations have been hindered by inconsistent results in different cellular contexts. Here we introduce a methodology to identify and quantify bias in signal transduction across the plasma membrane without contributions from feedback loops and system bias. We apply the...

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