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Article

Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling.

The Journal of biological chemistry - 1 Jul 2021

Pascarelli Stefano, Merzhakupova Dalmira, Uechi Gen-Ichiro, Laurino Paola

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a membrane-anchored tyrosine kinase that is able to selectively respond to multiple extracellular stimuli. Previous studies have indicated that the modularity of this system may be caused by ligand-induced differences in the stability of the receptor dimer. However, this hypothesis has not been explored using single-mutant ligands thus far. Herein, we developed a new...

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Identifiers

PMID: 34126069
DOI: 10.1016/j.jbc.2021.100872
PMCID: PMC8259408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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