Article

An integrated mechanistic and data-driven computational model predicts cell responses to high- and low-affinity EGFR ligands

2023-06-26

Abstract excerpt

<h4>ABSTRACT</h4> The biophysical properties of ligand binding heavily influence the ability of receptors to specify cell fates. Understanding the rules by which ligand binding kinetics impact cell phenotype is challenging, however, because of the coupled information transfers that occur from receptors to downstream signaling effectors and from effectors to phenotypes. Here, we address that issue by developing an...

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Literature Corpus work: 5e021cbe-a479-574d-a7af-843b2a51ac8f
DOI: 10.1101/2023.06.25.543329

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