Article

Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

2019-03-21

Abstract excerpt

<h4>Introductory paragraph</h4> The mechanisms that underpin how insertions or deletions (indels) become fixed in DNA have primarily been ascribed to replication-related and/or double-strand break (DSB)-related processes. We introduce a novel way to evaluate indels, orientating them relative to gene transcription. In so doing, we reveal a number of surprising findings: First, there is a transcriptional strand asy...

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Literature Corpus work: 53361e8a-29dd-5d56-84a5-9d39a8be9162
DOI: 10.1101/584342

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