Article
The mutational profile of the yeast genome is shaped by replication.
Molecular biology and evolution - 1 Mar 2012
Agier Nicolas, Fischer Gilles
Abstract excerpt
Despite the scrutiny that has been directed for years at the yeast genome, relatively little is known about the impact of replication on the substitution dynamics in Saccharomyces cerevisiae. Here, we show that the mutation rate increases with the replication timing by more than 30% between the earliest and the latest replicating regions. In addition, we found a mutational asymmetry associated with the polarity...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.