Article
Exponential decay of GC content detected by strand-symmetric substitution rates influences the evolution of isochore structure.
Molecular biology and evolution - 1 Feb 2008
Karro J E, Peifer M, Hardison R C, Kollmann M, von Grünberg H H
Abstract excerpt
The distribution of guanine and cytosine nucleotides throughout a genome, or the GC content, is associated with numerous features in mammals; understanding the pattern and evolutionary history of GC content is crucial to our efforts to annotate the genome. The local GC content is decaying toward an equilibrium point, but the causes and rates of this decay, as well as the value of the equilibrium point, remain...
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