Article
The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2011
van der Velden Yme U, Wang Liqin, Zevenhoven John, van Rooijen Ellen, van Lohuizen Maarten, Giles Rachel H, Clevers Hans, Haramis Anna-Pavlina G
Abstract excerpt
Mutations in the serine-threonine kinase (LKB1) lead to a gastrointestinal hamartomatous polyposis disorder with increased predisposition to cancer (Peutz-Jeghers syndrome). LKB1 has many targets, including the AMP-activated protein kinase (AMPK) that is phosphorylated under low-energy conditions. AMPK phosphorylation in turn, affects several processes, including inhibition of the target of rapamycin (TOR)...
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