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Article

LKB1 and AMPK maintain epithelial cell polarity under energetic stress.

The Journal of cell biology - 7 May 2007

Mirouse Vincent, Swick Lance L, Kazgan Nevzat, St Johnston Daniel, Brenman Jay E

Abstract excerpt

LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and the adenosine 5'monophosphate-activated kinase (AMPK). This has led to the hypothesis that LKB1 acts as a tumor suppressor because it is required to maintain cell pola...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17470638
DOI: 10.1083/jcb.200702053
PMCID: PMC2064817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17470638-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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