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Article

LKB1 and AMPK maintain epithelial cell polarity under energetic stress.

The Journal of cell biology - 7 May 2007

Mirouse Vincent, Swick Lance L, Kazgan Nevzat, St Johnston Daniel, Brenman Jay E

Abstract excerpt

LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and the adenosine 5'monophosphate-activated kinase (AMPK). This has led to the hypothesis that LKB1 acts as a tumor suppressor because it is required to maintain cell polarity and growth control through PAR-1 and AMPK, respectively. However, the genetic analysis of LKB1-AMPK signaling in...

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Identifiers

PMID: 17470638
DOI: 10.1083/jcb.200702053
PMCID: PMC2064817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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