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Article

The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress.

Scientific reports - 4 Aug 2017

Mans Laurie A, Querol Cano Laia, van Pelt Jason, Giardoglou Panagiota, Keune Willem-Jan, Haramis Anna-Pavlina G

Abstract excerpt

Autophagy is an evolutionarily conserved process that degrades cellular components to restore energy homeostasis under limited nutrient conditions. How this starvation-induced autophagy is regulated at the whole-body level is not fully understood. Here, we show that the tumor suppressor Lkb1, which activates the key energy sensor AMPK, also regulates starvation-induced autophagy at the organismal level....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28779098
DOI: 10.1038/s41598-017-07116-9
PMCID: PMC5544676

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