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Article

LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism

1 Jul 2009

Abstract excerpt

Research on the LKB1 tumor suppressor protein mutated in cancer-prone Peutz-Jeghers patients has continued at a feverish pace following exciting developments linking energy metabolism and cancer development. This review summarizes the current state of research on the LKB1 tumor suppressor. The weight of the evidence currently indicates an evolutionary conserved role for the protein in the regulation of various...

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PMID: 19584313
DOI: 10.1152/physrev.00026.2008

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