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Article

Association of a functional polymorphism in the 3'-untranslated region of SPI1 with systemic lupus erythematosus.

Arthritis and rheumatism - 1 Mar 2011

Hikami Koki, Kawasaki Aya, Ito Ikue, Koga Minori, Ito Satoshi, Hayashi Taichi, Matsumoto Isao, Tsutsumi Akito, Kusaoi Makio, Takasaki Yoshinari, Hashimoto Hiroshi, Arinami Tadao, Sumida Takayuki, Tsuchiya Naoyuki

Abstract excerpt

OBJECTIVE: SPI1, also referred to as PU.1, is an Ets family transcription factor that interacts with IRF2, IRF4, and IRF8. In view of the significance of the type I interferon pathway in systemic lupus erythematosus (SLE), this study was undertaken to investigate a possible association between SPI1 polymorphisms and SLE. METHODS: A case-control association study was performed using 6 tag single-nucleotide...

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Identifiers

PMID: 21360505
DOI: 10.1002/art.30188

Genes

SPI1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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