Article
Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.
Arthritis research & therapy - 1 Jan 2008
Kawasaki Aya, Ito Ikue, Hikami Koki, Ohashi Jun, Hayashi Taichi, Goto Daisuke, Matsumoto Isao, Ito Satoshi, Tsutsumi Akito, Koga Minori, Arinami Tadao, Graham Robert R, Hom Geoffrey, Takasaki Yoshinari, Hashimoto Hiroshi, Behrens Timothy W, Sumida Takayuki, Tsuchiya Naoyuki
Abstract excerpt
INTRODUCTION: Recent studies identified STAT4 (signal transducers and activators of transcription-4) as a susceptibility gene for systemic lupus erythematosus (SLE). STAT1 is encoded adjacently to STAT4 on 2q32.2-q32.3, upregulated in peripheral blood mononuclear cells from SLE patients, and functionally relevant to SLE. This study was conducted to test whether STAT4 is associated with SLE in a Japanese...
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