Association of functional polymorphisms in interferon regulatory factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study.

doi:10.1371/journal.pone.0109764

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Article

Association of functional polymorphisms in interferon regulatory factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study.

PloS one - 1 Jan 2014

Kawasaki Aya, Furukawa Hiroshi, Nishida Nao, Warabi Eiji, Kondo Yuya, Ito Satoshi, Matsumoto Isao, Kusaoi Makio, Amano Hirofumi, Suda Akiko, Nagaoka Shouhei, Setoguchi Keigo, Nagai Tatsuo, Hirohata Shunsei, Shimada Kota, Sugii Shoji, Okamoto Akira, Chiba Noriyuki, Suematsu Eiichi, Ohno Shigeru, Katayama Masao, Okamoto Akiko, Kono Hajime, Tokunaga Katsushi, Takasaki Yoshinari, Hashimoto Hiroshi, Sumida Takayuki, Tohma Shigeto, Tsuchiya Naoyuki

Abstract excerpt

Interferon regulatory factor 2 (IRF2) negatively regulates type I interferon (IFN) responses, while it plays a role in induction of Th1 differentiation. Previous linkage and association studies in European-American populations suggested genetic role of IRF2 in systemic lupus erythematosus (SLE); however, this observation has not yet been confirmed. No studies have been reported in the Asian populations. Here we...

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PMID: 25285625
DOI: 10.1371/journal.pone.0109764
PMCID: PMC4186848

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