Article
Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms.
Arthritis and rheumatism - 1 Mar 2008
Kawasaki Aya, Kyogoku Chieko, Ohashi Jun, Miyashita Risa, Hikami Koki, Kusaoi Makio, Tokunaga Katsushi, Takasaki Yoshinari, Hashimoto Hiroshi, Behrens Timothy W, Tsuchiya Naoyuki
Abstract excerpt
OBJECTIVE: To determine whether the IRF5 gene, which encodes interferon regulatory factor 5, is associated with systemic lupus erythematosus (SLE) in a Japanese population. METHODS: A case-control study was performed in 277 SLE patients and 201 healthy controls. Associations between the IRF5 genotype and levels of messenger RNA (mRNA) for interferon (IFN) pathway genes were examined using an mRNA expression...
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