Article
Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells.
The Journal of rheumatology - 1 Mar 2010
Löfgren Sara E, Yin Hong, Delgado-Vega Angelica M, Sanchez Elena, Lewén Susanna, Pons-Estel Bernardo A, Witte Torsten, D'Alfonso Sandra, Ortego-Centeno Norberto, Martin Javier, Alarcón-Riquelme Marta E, Kozyrev Sergey V
Abstract excerpt
OBJECTIVE: We examined the genetic association of the promoter insertion/deletion (indel) in IRF5 gene with systemic lupus erythematosus (SLE) in distinct populations and assessed its role in gene expression. METHODS: Four IRF5 polymorphisms were genotyped in 1488 SLE patients and 1466 controls....
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