Article
Minor C allele of the SNP rs7873784 associated with rheumatoid arthritis and type-2 diabetes mellitus binds PU.1 and enhances TLR4 expression.
Biochimica et biophysica acta. Molecular basis of disease - 1 Mar 2020
Korneev Kirill V, Sviriaeva Ekaterina N, Mitkin Nikita A, Gorbacheva Alisa M, Uvarova Aksinya N, Ustiugova Alina S, Polanovsky Oleg L, Kulakovskiy Ivan V, Afanasyeva Marina A, Schwartz Anton M, Kuprash Dmitry V
Abstract excerpt
Toll-like receptor 4 (TLR4) is an innate immunity receptor predominantly expressed on myeloid cells and involved in the development of various diseases, many of them with complex genetics. Here we present data on functionality of single nucleotide polymorphism rs7873784 located in the 3'-untranslated region (3'-UTR) of TLR4 gene and associated with various pathologies involving chronic inflammation. We...
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