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CRISPRi screens identify the lncRNA, <i>LOUP,</i> as a multifunctional locus regulating macrophage differentiation epigenetically and inflammatory signaling through a short, encoded peptide

2023-12-20

Abstract excerpt

Long non-coding RNAs (lncRNAs) account for the largest portion of RNA from the transcriptome, yet most of their functions remain unknown. Here we performed two independent high-throughput CRISPRi screens to understand the role of lncRNAs in monocyte function and differentiation. The first was a reporter-based screen to identify lncRNAs that regulate TLR4-NFkB signaling in human monocytes and the second screen iden...

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Identifiers and source

Literature Corpus work
02fbc21b-bac6-5597-9b90-ee2fcc7f4e5f
DOI
10.1101/2023.12.19.572453
Open publication

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CRISPRi screens identify the lncRNA, <i>LOUP,</i> as a multifunctional locus regulating macrophage differentiation epigenetically and inflammatory signaling through a short, encoded peptideDOI 10.1101/2023.12.19.572453
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