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Article

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.

Molecular biology of the cell - 15 Apr 2011

Kang Jungseog, Chaudhary Jaideep, Dong Hui, Kim Soonjoung, Brautigam Chad A, Yu Hongtao

Abstract excerpt

Human Shugoshin 1 (Sgo1) protects centromeric sister-chromatid cohesion during prophase and prevents premature sister-chromatid separation. Heterochromatin protein 1 (HP1) has been proposed to protect centromeric sister-chromatid cohesion by directly targeting Sgo1 to centromeres in mitosis. Here we show that HP1α is targeted to mitotic centromeres by INCENP, a subunit of the chromosome passenger complex (CPC)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromobox Protein Homolog 5

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Source

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Identifiers

PMID: 21346195
DOI: 10.1091/mbc.E11-01-0009
PMCID: PMC3078076

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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