Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules.

Cell cycle (Georgetown, Tex.) - 1 May 2006

Suzuki Hideaki, Akiyama Nobutake, Tsuji Megumi, Ohashi Toya, Saito Saburo, Eto Yoshikatsu

Abstract excerpt

The conserved protein Shugoshin (Sgo) plays a role in the maintenance of centromeric cohesion in mitosis and meiosis. Human Shugoshin (hSgo) was first identified as an overexpressed protein in breast cancers. Here we demonstrate that hSgo mediates kinetochore-driven formation of kinetochore -microtubules (MTs) during bipolar spindle assembly. The regulated overexpression of full-length hSgo, or of truncated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chromosomal Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Kinetochores

Share to Microtubules

Share to Mitosis

Share to Spindle Apparatus

Share to Transfection

Source

Identifiers

PMID: 16687935
DOI: 10.4161/cc.5.10.2747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules.PMID 16687935Read ↗

Structure and function of the PP2A-shugoshin interaction.Semantic proximity Read ↗

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassemblySemantic proximity Read ↗

Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.Semantic proximity Read ↗

Shugoshin: From a Perspective of Clinical DisordersSemantic proximity Read ↗

D-box is required for the degradation of human Shugoshin and chromosome alignment.Semantic proximity Read ↗

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.Semantic proximity Read ↗

SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinomaSemantic proximity Read ↗

The Caenorhabditis elegans Shugoshin regulates TAC-1 in ciliaSemantic proximity Read ↗

Meiotic shugoshins differ from mitotic ones by arginine-reach C-terminal motif in yeast, plant, animals, and humanSemantic proximity Read ↗

A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions.Semantic proximity Read ↗

A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae.Semantic proximity Read ↗

Human Sgo1 downregulation leads to chromosomal instability in colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.