Article
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
Developmental cell - 1 Jul 2006
Resnick Tamar D, Satinover David L, MacIsaac Fiona, Stukenberg P Todd, Earnshaw William C, Orr-Weaver Terry L, Carmena Mar
Abstract excerpt
The chromosomal passenger complex protein INCENP is required in mitosis for chromosome condensation, spindle attachment and function, and cytokinesis. Here, we show that INCENP has an essential function in the specialized behavior of centromeres in meiosis. Mutations affecting Drosophila incenp profoundly affect chromosome segregation in both meiosis I and II, due, at least in part, to premature sister chromatid...
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