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Aurora B kinase activity–dependent and –independent functions of the chromosomal passenger complex in regulating sister chromatid cohesion

7 Dec 2018

Abstract excerpt

The chromosomal passenger complex (CPC) is a master regulator of mitosis. CPC consists of inner centromere protein (INCENP), Survivin, Borealin, and the kinase Aurora B and plays key roles in regulating kinetochore-microtubule attachments and spindle assembly checkpoint signaling. However, the role of CPC in sister chromatid cohesion, mediated by the cohesin complex, remains incompletely understood. Here, we show...

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PMID: 30523151
DOI: 10.1074/jbc.ra118.005978

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Aurora B kinase activity–dependent and –independent functions of the chromosomal passenger complex in regulating sister chromatid cohesionPMID 30523151Read ↗

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.Semantic proximity Read ↗

Two histone marks establish the inner centromere and chromosome bi-orientation.Semantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.Semantic proximity Read ↗

INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.Semantic proximity Read ↗

The chromosomal passenger complex: one for all and all for one.Semantic proximity Read ↗

Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis.Semantic proximity Read ↗

Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cellsSemantic proximity Read ↗

A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.Semantic proximity Read ↗

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian developmentSemantic proximity Read ↗

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.Semantic proximity Read ↗

CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.Semantic proximity Read ↗

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