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Article

D-box is required for the degradation of human Shugoshin and chromosome alignment.

Biochemical and biophysical research communications - 8 Jun 2007

Fu Guosheng, Hua Shasha, Ward Tarsha, Ding Xia, Yang Yong, Guo Zhen, Yao Xuebiao

Abstract excerpt

Chromosome segregation and proper alignment in mitosis relies on cohesion between sister chromatids and the interaction of the kinetochore with spindle microtubules. Vertebrate Sgo 1 localizes to kinetochores and is required to prevent premature sister centromere separation in mitosis. Sgo 1 is degraded by the anaphase-promoting complex, allowing the separation of sister centromeres in anaphase. However, little...

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Mitosis
Anaphase
Aurora Kinase B
Aurora Kinases
Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Chromosomal Proteins, Non-Histone

Chromosome Segregation

Microscopy, Confocal

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PMID: 17448445
DOI: 10.1016/j.bbrc.2007.03.204

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D-box is required for the degradation of human Shugoshin and chromosome alignment.PMID 17448445Read ↗

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.Semantic proximity Read ↗

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Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.Semantic proximity Read ↗

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassemblySemantic proximity Read ↗

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.Semantic proximity Read ↗

A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions.Semantic proximity Read ↗

A genome-wide screen identifies genes required for centromeric cohesion.Semantic proximity Read ↗

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.Semantic proximity Read ↗

Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules.Semantic proximity Read ↗

Meiotic shugoshins differ from mitotic ones by arginine-reach C-terminal motif in yeast, plant, animals, and humanSemantic proximity Read ↗

Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.Semantic proximity Read ↗

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