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Article

A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions.

Current biology : CB - 24 May 2005

Hamant Olivier, Golubovskaya Inna, Meeley Robert, Fiume Elisa, Timofejeva Ljuda, Schleiffer Alexander, Nasmyth Kim, Cande W Zacheus

Abstract excerpt

During meiosis, sequential release of sister chromatid cohesion (SSC) during two successive nuclear divisions allows the production of haploid gametes from diploid progenitor cells. Release of SSC along chromosome arms allows first a reductional segregation of homologs, and, subsequently, release of centromeric cohesion at anaphase II allows the segregation of chromatids. The Shugoshin (SGO) protein family plays...

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Source

Identifiers

PMID: 15916952
DOI: 10.1016/j.cub.2005.04.049

Genes

REC8
SGO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions.PMID 15916952Read ↗

Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at anaphase I and by PATRONUS at interkinesis.Semantic proximity Read ↗

Meiotic shugoshins differ from mitotic ones by arginine-reach C-terminal motif in yeast, plant, animals, and humanSemantic proximity Read ↗

A genome-wide screen identifies genes required for centromeric cohesion.Semantic proximity Read ↗

Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.Semantic proximity Read ↗

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassemblySemantic proximity Read ↗

Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.Semantic proximity Read ↗

D-box is required for the degradation of human Shugoshin and chromosome alignment.Semantic proximity Read ↗

Sisters unbound is required for meiotic centromeric cohesion in Drosophila melanogaster.Semantic proximity Read ↗

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.Semantic proximity Read ↗

MGO3 and GIP1 act synergistically for the maintenance of centromeric cohesion.Semantic proximity Read ↗

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.Semantic proximity Read ↗

Structure and function of the PP2A-shugoshin interaction.Semantic proximity Read ↗

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