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Article

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.

Developmental cell - 1 May 2006

Tang Zhanyun, Shu Hongjun, Qi Wei, Mahmood Nadir A, Mumby Marc C, Yu Hongtao

Abstract excerpt

Loss of sister-chromatid cohesion triggers chromosome segregation in mitosis and occurs through two mechanisms in vertebrate cells: (1) phosphorylation and removal of cohesin from chromosome arms by mitotic kinases, including Plk1, during prophase, and (2) cleavage of centromeric cohesin by separase at the metaphase-anaphase transition. Bub1 and the MEI-S332/Shugoshin (Sgo1) family of proteins protect centromeric...

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Identifiers

PMID: 16580887
DOI: 10.1016/j.devcel.2006.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.PMID 16580887Read ↗

Structure and function of the PP2A-shugoshin interaction.Semantic proximity Read ↗

D-box is required for the degradation of human Shugoshin and chromosome alignment.Semantic proximity Read ↗

Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.Semantic proximity Read ↗

Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.Semantic proximity Read ↗

A genome-wide screen identifies genes required for centromeric cohesion.Semantic proximity Read ↗

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.Semantic proximity Read ↗

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.Semantic proximity Read ↗

Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.Semantic proximity Read ↗

Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.Semantic proximity Read ↗

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis ISemantic proximity Read ↗

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassemblySemantic proximity Read ↗

Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.Semantic proximity Read ↗

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