Article
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.
Developmental cell - 1 May 2006
Tang Zhanyun, Shu Hongjun, Qi Wei, Mahmood Nadir A, Mumby Marc C, Yu Hongtao
Abstract excerpt
Loss of sister-chromatid cohesion triggers chromosome segregation in mitosis and occurs through two mechanisms in vertebrate cells: (1) phosphorylation and removal of cohesin from chromosome arms by mitotic kinases, including Plk1, during prophase, and (2) cleavage of centromeric cohesin by separase at the metaphase-anaphase transition. Bub1 and the MEI-S332/Shugoshin (Sgo1) family of proteins protect centromeric...
Topics
- Cell Cycle Proteins
- Centromere
- Chromosome Segregation
- Gene Expression
- HeLa Cells
- Humans
- Mitosis
- Mutation
- Phosphoprotein Phosphatases
- Protein Binding
- Protein Kinases
- Protein Phosphatase 2
- Protein Serine-Threonine Kinases
- Protein Structure, Tertiary