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Article

Structure and function of the PP2A-shugoshin interaction.

Molecular cell - 28 Aug 2009

Xu Zheng, Cetin Bulent, Anger Martin, Cho Uhn Soo, Helmhart Wolfgang, Nasmyth Kim, Xu Wenqing

Abstract excerpt

Accurate chromosome segregation during mitosis and meiosis depends on shugoshin proteins that prevent precocious dissociation of cohesin from centromeres. Shugoshins associate with PP2A, which is thought to dephosphorylate cohesin and thereby prevent cleavage by separase during meiosis I. A crystal structure of a complex between a fragment of human Sgo1 and an AB'C PP2A holoenzyme reveals that Sgo1 forms a...

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Source

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Identifiers

PMID: 19716788
DOI: 10.1016/j.molcel.2009.06.031
PMCID: PMC2749713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Structure and function of the PP2A-shugoshin interaction.PMID 19716788Read ↗

Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.Semantic proximity Read ↗

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.Semantic proximity Read ↗

Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.Semantic proximity Read ↗

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassemblySemantic proximity Read ↗

D-box is required for the degradation of human Shugoshin and chromosome alignment.Semantic proximity Read ↗

Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.Semantic proximity Read ↗

Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules.Semantic proximity Read ↗

Meiotic shugoshins differ from mitotic ones by arginine-reach C-terminal motif in yeast, plant, animals, and humanSemantic proximity Read ↗

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.Semantic proximity Read ↗

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.Semantic proximity Read ↗

Fighting of Casein kinase 1 and PP2A/Shugoshin for cohesins during meiosis I.Semantic proximity Read ↗

A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions.Semantic proximity Read ↗

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