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Article

A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae.

Genetics - 1 Feb 2018

Buehl Christopher J, Deng Xiexiong, Luo Jianjun, Buranasudja Visarut, Hazbun Tony, Kuo Min-Hao

Abstract excerpt

Mitotic fidelity is ensured by achieving biorientation on all paired chromosomes. The key signal for proper chromosome alignment is the tension between sister chromatids created by opposing poleward force from the spindles. In the budding yeast, the tension-sensing function requires that the Shugoshin protein, Shugoshin 1, be recruited to the centromeres and the neighboring pericentric regions. Concerted actions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29242290
DOI: 10.1534/genetics.117.300606
PMCID: PMC5788522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae.PMID 29242290Read ↗

Histone h3 exerts a key function in mitotic checkpoint control.Semantic proximity Read ↗

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassemblySemantic proximity Read ↗

Meiotic shugoshins differ from mitotic ones by arginine-reach C-terminal motif in yeast, plant, animals, and humanSemantic proximity Read ↗

Structural basis for the functional role of the Shu complex in homologous recombination.Semantic proximity Read ↗

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.Semantic proximity Read ↗

Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.Semantic proximity Read ↗

Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.Semantic proximity Read ↗

Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at anaphase I and by PATRONUS at interkinesis.Semantic proximity Read ↗

Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins.Semantic proximity Read ↗

Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.Semantic proximity Read ↗

A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions.Semantic proximity Read ↗

Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids.Semantic proximity Read ↗

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