Article
Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at anaphase I and by PATRONUS at interkinesis.
Current biology : CB - 4 Nov 2013
Cromer Laurence, Jolivet Sylvie, Horlow Christine, Chelysheva Liudmila, Heyman Jefri, De Jaeger Geert, Koncz Csaba, De Veylder Lieven, Mercier Raphael
Abstract excerpt
BACKGROUND: At meiosis, two successive rounds of chromosome segregation lead to ploidy halving. This is achieved through a stepwise release of sister chromatid cohesion, along chromosome arms to allow homolog segregation at anaphase I and at centromeres to allow sister chromatid segregation at anaphase II. Cohesins, the protein complex that ensures cohesion, must then be protected at centromeres throughout...
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