Article
Rapid detection of the hepatitis B virus YMDD mutant using AllGlo™ probes.
Clinica chimica acta; international journal of clinical chemistry - 12 May 2011
Feng Zhao-lei, Yu Xiao-yan, Lu Zhi-ming, Geng Da-ying, Zhang Li, Chen Shi-jun
Abstract excerpt
BACKGROUND: The early detection of hepatitis B virus (HBV) mutants in clinical samples is important when monitoring chronic HBV patients with lamivudine-resistant mutations during lamivudine therapy. METHODS: The AllGlo™ probes were designed to distinguish between wild-type (YMDD) and mutant (YVDD and YIDD) strains of HBV. The sensitivity and specificity of the assay were evaluated using a series of diluted...
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