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Article

Direct detection of lamivudine-resistant hepatitis B virus mutants by a multiplex PCR using dual-priming oligonucleotide primers.

Journal of virological methods - 1 Apr 2008

Kim Jong-Kee, Lee Hyeon-Ji, Lee Young-Jo, Chun Jong-Yoon, Lee In-Kyoung, Lim Young-Suk, Suh Dong Jin, Ko Sun-Young, Kim Myeong Hee, Oh Heung-Bum

Abstract excerpt

Mutations in the YMDD motif of the hepatitis B virus (HBV) polymerase gene increase lamivudine resistance of HBV, highlighting the clinical importance of accurate and sensitive detection of HBV mutants. Using dual-priming oligonucleotide primer technology, an assay that can detect mutations at codons 180 (L528M) and 204 (YVDD, YIDD, and YSDD) by a single-step multiplex PCR was developed. This Seeplex Lami-DR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18291537
DOI: 10.1016/j.jviromet.2008.01.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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