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Article

Rapid detection of the hepatitis B virus YMDD mutant using TaqMan-minor groove binder probes.

Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2008

Hua Rui, Tanaka Yasuo, Fukai Kenichi, Tada Motohisa, Seto Motoko, Asaoka Yoshinari, Ohta Miki, Goto Tadashi, Kanai Fumihiko, Kato Naoya, Yoshida Haruhiko, Kawabe Takao, Yokosuka Osamu, Omata Masao

Abstract excerpt

BACKGROUND: TaqMan-minor groove binder (MGB) probes were used in a real-time PCR-based assay for the rapid and accurate detection of hepatitis B virus (HBV) YMDD mutants. METHODS: TaqMan-MGB probes were designed to distinguish between wild-type (YMDD) and mutant (YVDD and YIDD) strains of HBV. The detection limit and sensitivity of the assay were determined using a dilution series of a mixture of wild-type and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18602379
DOI: 10.1016/j.cca.2008.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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