Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of wild type and mutants of the YMDD motif of hepatitis B virus polymerase during lamivudine therapy.

Journal of gastroenterology and hepatology - 1 Dec 2003

Zhang Xinxin, Liu Chuanmiao, Gong Qiming, Zhang Shenying, Zhang Donghua, Lu Zhimeng, Wang Yuan

Abstract excerpt

BACKGROUND AND AIM: Long-term lamivudine treatment for chronic hepatitis B virus (HBV) infection induces the emergence of lamivudine resistant HBV YMDD mutant strains. The aim of the present study was to observe the clone evolution of YMDD wild type and mutant strains in pretreatment and post-tre...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine Transaminase
Share to Amino Acid Motifs
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, pol

Share to Hepatitis B

Share to Hepatitis B virus

Share to Lamivudine

Share to Reverse Transcriptase Inhibitors

Source

Identifiers

PMID: 14675262
DOI: 10.1046/j.1440-1746.2003.03176.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14675262-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of wild type and mutants of the YMDD motif of hepatitis B virus polymerase during lamivudine therapy.PMID 14675262Read ↗

[Natural YMDD motif mutations of HBV polymerase in the chronic hepatitis B virus infected patients].Semantic proximity Read ↗

Correlation of the occurrence of YMDD mutations with HBV genotypes, HBV-DNA levels, and HBeAg status in Chinese patients with chronic hepatitis B during lamivudine treatment.Semantic proximity Read ↗

Pre-existing YMDD mutants in treatment-naïve patients with chronic hepatitis B are not selected during lamivudine therapy.Semantic proximity Read ↗

Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine.Semantic proximity Read ↗

Clinical features of chronic hepatitis B patients with YMDD mutation after lamivudine therapy.Semantic proximity Read ↗

Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.Semantic proximity Read ↗

Clinical and virological characteristics of lamivudine resistance in chronic hepatitis B patients: a single center experience.Semantic proximity Read ↗

[Emergence and clinical significance of YMDD and HBeAg-related mutations during lamivudine treatment].Semantic proximity Read ↗

Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy.Semantic proximity Read ↗

[Types and emergence time of YMDD motif mutation in hepatitis B virus polymerase gene during lamivudine treatment].Semantic proximity Read ↗

Rate of YMDD motif mutants in lamivudine-untreated Iranian patients with chronic hepatitis B virus infection.Semantic proximity Read ↗

Detection of YMDD motif mutations in some lamivudine-untreated asymptomatic hepatitis B virus carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.