Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantification of lamivudine-resistant hepatitis B virus mutants by type-specific TaqMan minor groove binder probe assay in patients with chronic hepatitis B.

Annals of clinical biochemistry - 1 Jan 2008

Yoshida Shigeru, Hige Shuhei, Yoshida Miyuki, Yamashita Naoki, Fujisawa Shin-ichi, Sato Kaori, Kitamura Tadashiro, Nishimura Masaharu, Chuma Makoto, Asaka Masahiro, Chiba Hitoshi

Abstract excerpt

BACKGROUND: Lamivudine (LAM)-resistant hepatitis B virus (HBV) with mutations in the polymerase region frequently appears after long-term use of LAM. Several methods allowing detection of mutant strains (YIDD, YVDD) have been reported, but they have no quantitative characteristics. In this study, we explored a unique approach for quantification of each mutant strain. METHODS: A method for detection and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Probes
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Lamivudine

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Share to Taq Polymerase

Source

Identifiers

PMID: 18275675
DOI: 10.1258/acb.2007.006219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantification of lamivudine-resistant hepatitis B virus mutants by type-specific TaqMan minor groove binder probe assay in patients with chronic hepatitis B.PMID 18275675Read ↗

Rapid detection of the hepatitis B virus YMDD mutant using TaqMan-minor groove binder probes.Semantic proximity Read ↗

Rapid detection of the hepatitis B virus YMDD mutant using AllGlo™ probes.Semantic proximity Read ↗

Detection of YMDD mutants using universal template real-time PCR.Semantic proximity Read ↗

Rapid quantitation of lamivudine-resistant mutants in lamivudine treated and untreated patients with chronic hepatitis B virus infection.Semantic proximity Read ↗

Sensitive assay for quantification of hepatitis B virus mutants by use of a minor groove binder probe and peptide nucleic acids.Semantic proximity Read ↗

Detection of YMDD mutation using mutant-specific primers in chronic hepatitis B patients before and after lamivudine treatment.Semantic proximity Read ↗

Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: a novel approach.Semantic proximity Read ↗

Hepatitis B virus quantification and detection of YMDD mutants in a single reaction by real-time PCR and annealing curve analysis.Semantic proximity Read ↗

Evolution of wild type and mutants of the YMDD motif of hepatitis B virus polymerase during lamivudine therapy.Semantic proximity Read ↗

Quantitation of hepatitis B lamivudine resistant mutants by real-time amplification refractory mutation system PCR.Semantic proximity Read ↗

Rapid detection of lamivudine-resistant hepatitis B virus mutations by PCR-based methods.Semantic proximity Read ↗

Direct detection of lamivudine-resistant hepatitis B virus mutants by a multiplex PCR using dual-priming oligonucleotide primers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.