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Article

Detection of YMDD mutation using mutant-specific primers in chronic hepatitis B patients before and after lamivudine treatment.

World journal of gastroenterology - 7 Sept 2006

Lee Cha-Ze, Lee Hsuan-Shu, Huang Guan-Tarn, Yang Pei-Ming, Sheu Jin-Chuan

Abstract excerpt

AIM: To develop a PCR assay using mutant-specific primers to detect mutation of tyrosine-methionine-aspartate-aspartate (YMDD) motif of HBV to tyrosine-valine-aspartate-aspartate (YVDD) or tyrosine-isoleucine-aspartate-aspartate (YIDD). METHODS: Cloned wild-type and mutant HBV sequences were used as templates to test the sensitivity and specificity of the assay. A variety of primer construction, primer...

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Source

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Identifiers

PMID: 16981258
DOI: 10.3748/wjg.v12.i33.5301
PMCID: PMC4088195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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