Article
Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy.
Seizure - 1 Jun 2011
Haerian B S, Lim K S, Mohamed E H M, Tan H J, Tan C T, Raymond A A, Wong C P, Wong S W, Mohamed Z
Abstract excerpt
It is proposed that overexpression of P-glycoprotein (P-gp), encoded by the ABC subfamily B member 1 (ABCB1) gene, is involved in resistance to antiepileptic drugs (AEDs) in about 30% of patients with epilepsy. Genetic variation and haplotype patterns are population specific which may cause different phenotypes such as response to AEDs. Although several studies examined the link between the common polymorphisms...
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